Acute Neuronal Injury: The Role of Excitotoxic Programmed by PDF

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ISBN-10: 038773225X

ISBN-13: 9780387732251

Denson G. Fujikawa 2+ within the early Eighties it used to be famous that over the top Ca inflow, most likely via 2+ 2+ voltage-gated Ca channels, with a resultant elevate in intracellular Ca, was once linked to neuronal dying from cerebral ischemia, hypoglycemia, and standing epilepticus (Siejo 1981). Calcium activation of phospholipases, with arachidonic acid accumulation and its oxidation, producing loose radicals, was once regarded as a possible mechanism wherein neuronal harm happens. In cerebral ischemia and a couple of+ hypoglycemia, power failure used to be considered the cause of over the top Ca inflow, while in prestige epilepticus it used to be concept that repetitive depolarizations have been liable (Siejo 1981). in the meantime, John Olney chanced on that monosodium glutamate, the nutrition additive, whilst given to immature rats, was once linked to neuronal degeneration within the arcuate nucleus of the hypothalamus, which lacks a blood-brain barrier (Olney 1969). He up this remark with a sequence of observations within the Nineteen Seventies that management of kainic acid, which we now comprehend prompts the GluR5-7 subtypes of glutamate receptor, and different glutamate analogues, brought on not just post-synaptic cytoplasmic swelling, but in addition dark-cell degeneration of neurons, whilst seen through electron microscopy (Olney 1971; Olney et al. 1974).

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Cmd=Retrieve&db=PubMed&list_ uids=11525324&dopt=Abstract • Critical dimensions affecting imitation performance of patients with ideomotor apraxia. Author(s): Toraldo A, Reverberi C, Rumiati RI. Source: Cortex. 2001 December; 37(5): 737-40. No Abstract Available. cmd=Retrieve&db=PubMed&list_ uids=11804229&dopt=Abstract • Crossed buccofacial apraxia. Author(s): Mani RB, Levine DN. Source: Archives of Neurology. 1988 May; 45(5): 581-4. cmd=Retrieve&db=PubMed&list_ uids=3358712&dopt=Abstract • Crossed face apraxia.

Source: Journal of Neurology, Neurosurgery, and Psychiatry. 1981 April; 44(4): 305-8. cmd=Retrieve&db=PubMed&list_ uids=7241157&dopt=Abstract • Gait apraxia in normal-pressure hydrocephalus: patterns of movement and muscle activation. Author(s): Knutsson E, Lying-Tunell U. Source: Neurology. 1985 February; 35(2): 155-60. cmd=Retrieve&db=PubMed&list_ uids=3969202&dopt=Abstract • Gaucher disease with oculomotor apraxia and cardiovascular calcification (Gaucher type IIIC). Author(s): Bohlega S, Kambouris M, Shahid M, Al Homsi M, Al Sous W.

Author(s): Weistuch L, Schiff-Myers NB. Source: Journal of Speech and Hearing Research. 1996 June; 39(3): 668-71. cmd=Retrieve&db=PubMed&list_ uids=8783144&dopt=Abstract • Coarticulation patterns in children with developmental apraxia of speech. Author(s): Nijland L, Maassen B, Van der Meulen S, Gabreels F, Kraaimaat FW, Schreuder R. Source: Clinical Linguistics & Phonetics. 2002 September; 16(6): 461-83. cmd=Retrieve&db=PubMed&list_ uids=12469451&dopt=Abstract • Cognition in action: testing a model of limb apraxia.

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Acute Neuronal Injury: The Role of Excitotoxic Programmed Cell Death Mechanisms

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